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PLATELET-RICH FIBRIN & HAIR LOSS

Understanding PRF for Hair Loss

A Platelet-Based Treatment Prepared From Your Own Blood

Platelet-rich fibrin, commonly called PRF, is prepared from a small sample of your own blood. The sample is processed at a lower centrifugation speed to create a platelet-rich preparation that also contains a fibrin matrix.

PRF has been studied as an option for certain types of hair thinning, including androgenetic alopecia. Research is still developing, and treatment protocols and individual responses can vary.

PRF is not FDA-approved specifically for the treatment of hair loss. Individual results vary.

HOW PRF IS PREPARED

From a Small Blood Draw to Platelet-Rich Fibrin

PRF begins with a sample of your own blood. The sample is processed using a centrifuge to create a platelet-rich preparation that contains a fibrin matrix. Preparation methods can vary, and there is not yet one universally standardized PRF protocol.

01

Blood Is Collected

A small sample of blood is drawn, much like a routine blood draw, and is then prepared for centrifugation as part of the PRF process.

Illustration of a blood sample being collected for platelet-rich fibrin (PRF) preparation

02

PRF Is Separated

The blood is processed in a centrifuge to create a platelet-rich preparation with fibrin. Many PRF protocols use lower centrifugation forces than PRP preparation.

Illustration of blood samples being processed in a centrifuge to prepare platelet-rich fibrin (PRF)

03

PRF Is Applied to the Scalp

The prepared PRF can then be administered into targeted areas of the scalp according to the individual treatment plan.

Illustration of platelet-rich fibrin (PRF) being injected into targeted areas of the scalp

PRF & PRP

How Is PRF Different From PRP?

PRF and PRP are both prepared from a person’s own blood and are used as platelet-based treatments. The main differences are in how the blood is processed and the final composition of the preparation.

PRF

Platelet-Rich Fibrin

PRF is typically prepared using a different centrifugation approach and contains a fibrin matrix along with concentrated platelets. This gives PRF a different physical composition from PRP.

PRP

Platelet-Rich Plasma

PRP is processed to create a concentrated platelet-rich plasma that can be injected into targeted areas of the scalp. Preparation methods vary depending on the system and protocol being used.

Neither option is automatically the right choice for everyone.
The available research on PRF is still developing, and there is not yet a standardized preparation protocol or enough evidence to say PRF is definitively superior to PRP for hair loss.

WHO MAY CONSIDER PRF

Is PRF Appropriate for Everyone?

PRF is not used the same way for every type of hair loss. Hair loss pattern, existing density, scalp condition, medical history, and individual goals should all be considered before deciding whether PRF belongs in a treatment plan.

Early or Progressive Thinning

PRF may be discussed for people noticing thinning in areas where hair is still present and changes are becoming more noticeable.

Pattern Hair Loss

PRF has been studied in people with androgenetic alopecia, commonly called male- or female-pattern hair loss.

Looking for a Non-Surgical Option

Some people explore PRF because it does not involve transplant surgery and can be considered as part of a broader hair-restoration plan.

Able to Follow a Treatment Plan

PRF is typically approached as a series rather than a one-time treatment, with follow-up based on the individual response and treatment plan.

Hair loss can have many causes, an evaluation is important before deciding whether PRF or another option may be appropriate.

COMMON QUESTIONS

PRF for Hair Loss FAQs

PRF contains concentrated platelets within a fibrin-rich preparation. Platelets release naturally occurring signaling proteins and growth factors involved in normal healing and tissue communication. Researchers are studying how this environment may interact with existing hair follicles.

Both are prepared from your own blood, but they are processed differently. PRF typically uses a different centrifugation approach and includes a fibrin matrix, giving the final preparation a different composition from PRP. Current research has not established PRF as definitively better than PRP for hair loss.

Most published PRF hair-loss research has focused on androgenetic alopecia, commonly known as male- or female-pattern hair loss.

There is not yet one universally accepted PRF treatment schedule. The number and timing of treatments can vary based on the protocol being used and the individual treatment plan.

Yes. Depending on the individual, PRF may be discussed alongside other non-surgical or surgical hair-restoration options rather than as a stand-alone approach.

PRF is not FDA-approved specifically for the treatment of hair loss. Individual results and treatment recommendations vary.

SCHEDULE A HAIR & SCALP CONSULTATION

Sources & Further Reading

Shrestha S, et al. — Platelet-rich fibrin: A review of its role as a new treatment in androgenetic alopecia. Journal of Cosmetic Dermatology, 2024.

Yao S, et al. — New tool in our arsenal: efficacy of injectable platelet-rich fibrin (i-PRF) in androgenetic alopecia treatment. Archives of Dermatological Research, 2025.