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| 5520 McNeely Drive, #203 - Raleigh, NC 27612

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PLATELET-RICH PLASMA & SKIN

Understanding PRP for Facial Skin

PRP, Microneedling & Facial Rejuvenation Research

Platelet-rich plasma, commonly called PRP, is prepared from a small sample of a person’s own blood. The blood is processed to concentrate the platelet-rich portion, which contains naturally occurring proteins and signaling factors involved in normal tissue repair.

PRP has been studied in aesthetic medicine for concerns such as skin texture, fine lines, and signs of facial aging. Research continues to evaluate the most effective preparation methods, treatment techniques, and protocols.

PRP is not FDA-approved specifically for facial rejuvenation. Individual responses and treatment recommendations vary.

UNDERSTANDING PRP

Prepared From Your Own Blood

PRP begins with a small blood sample. That sample is processed in a centrifuge to separate and concentrate the platelet-rich portion before it is used as part of the treatment plan.

Blood Is Collected

A small amount of blood is drawn, similar to a routine blood draw.

Platelets Are Concentrated

It is processed to separate the platelet-rich portion from other components.

PRP Is Prepared for Use

The platelet-rich plasma can then be used according to the treatment protocol.

THE TREATMENT PROCESS

How Microneedling Fits Into Facial Treatment

Microneedling uses very small needles to create controlled microchannels in the skin. The procedure has been studied for facial rejuvenation, including concerns such as texture, fine lines, photoaging, and skin laxity.

At Jernigan’s, PRP may be incorporated into a facial microneedling treatment according to the individual treatment plan.

Skin Preparation

The skin is cleansed and prepared before treatment begins.

Microneedling

A microneedling device is used in areas with settings appropriate for the area.

PRP

PRP is incorporated into the treatment according to the treatment protocol.

FDA states that cleared microneedling devices have not been cleared specifically for delivering PRP or other products into the skin.

CURRENT EVIDENCE

PRP and Facial Rejuvenation Research

Minimal illustration of a woman’s face with fine lines around the eye and a subtle sparkle accent

Fine Lines & Wrinkles

Clinical studies have evaluated changes in the appearance of facial lines and wrinkles following PRP treatment.

Minimal illustration of a woman’s face with a soft dotted pattern across the cheek representing skin texture

Skin Texture

Skin smoothness and texture are commonly assessed outcomes in PRP facial-rejuvenation research.

Minimal illustration of a woman’s face with water droplets and glowing skin representing hydration

Hydration & Appearance

Some studies have evaluated changes in hydration and overall skin appearance following treatment.

Minimal illustration of a woman’s face with a magnified view of layered skin structures within the cheek

Dermal Changes

Researchers have also examined biological and structural changes within the skin after PRP treatment.

Research findings are encouraging in some areas, but treatment methods vary considerably between studies.

PERSONALIZED SKIN CARE

Is This Approach Appropriate for Everyone?

Skin treatments should be selected according to the individual rather than based on a single concern or trend.

Fine Lines

For people interested in discussing non-surgical approaches to early signs of facial aging.

Uneven Texture

Microneedling has been studied for improving the appearance of skin texture.

Photoaged Skin

Some research has evaluated microneedling and PRP in skin showing signs associated with sun exposure and aging.

Personalized Treatment Planning

Medical history, skin condition, medications, previous procedures, and individual goals should be reviewed before treatment.

AFTER TREATMENT

What the Skin May Look Like Afterwards

Temporary redness, sensitivity, dryness, or light flaking can occur following microneedling. These effects generally resolve as the skin recovers. Studies of microneedling report transient redness as one of the most common side effects.

Temporary Redness

The skin may appear pink or red immediately after treatment.

Increased Sensitivity

Skin can temporarily be more sensitive to products, heat, and sunlight.

Gentle Aftercare

A simple skin-care routine and sun protection are important while recovering.

UNDERSTANDING YOUR OPTIONS

Different Treatments Work Differently

PRP + Microneedling

Microneedling procedure + platelet-rich plasma prepared from your own blood.

Red Light Facial

Uses light-based technology as part of a non-invasive skin-care treatment.

Radiofrequency Facial

Controlled radiofrequency energy as part of a non-surgical skin-treatment approach.

The appropriate option depends on the skin concern, medical history, treatment goals, and individual assessment.

RESEARCH & REFERENCES

Learn More About PRP & Microneedling

PRP and microneedling have both been studied in facial rejuvenation research. Treatment methods, PRP preparation, application techniques, and study outcomes vary, and research continues to evaluate the most effective protocols.

PRP for Facial Rejuvenation — Systematic Review
A 2025 systematic review evaluated clinical studies of PRP used for facial rejuvenation, including research examining wrinkles, skin texture, hydration, and other signs of skin aging. The authors noted encouraging findings while also emphasizing differences in treatment techniques and the need for additional research. PubMed
View the study on PubMed

PRP and Photoaged Facial Skin — Randomized Clinical Trial
A randomized split-face clinical trial published in JAMA Dermatology compared PRP injections with saline. Participants reported greater improvement in texture and wrinkles on the PRP-treated side at six months, although masked physician assessments did not find significant differences for several measured photoaging outcomes. PubMed
View the clinical trial on PubMed

Microneedling for Facial Rejuvenation — Systematic Review
A 2025 systematic review evaluated 21 studies involving microneedling for facial rejuvenation. Commonly studied outcomes included wrinkles, skin texture, photoaging, and skin laxity, while the authors noted that treatment methods and outcome measurements were not standardized across studies. PubMed
View the study on PubMed

FDA Information on Microneedling Devices
The FDA provides information about cleared microneedling devices, potential risks, and their authorized uses. The FDA also states that microneedling devices have not been cleared for delivering PRP or other blood products into the skin. U.S. Food and Drug Administration
View FDA Microneedling Device Information

Published studies may use different PRP preparation methods, microneedling devices, treatment techniques, and protocols than those used at Jernigan’s. Research findings do not guarantee individual results.